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Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

Human fibroblasts whose lifespan in culture has been extended by expression of a viral oncogene eventually undergo a growth crisis marked by failure to proliferate. It has been proposed that telomere shortening in these cells is the property that limits their proliferation. Here we report that ectop...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhu, Jiyue, Wang, He, Bishop, J. Michael, Blackburn, Elizabeth H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1999
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC22361/
https://ncbi.nlm.nih.gov/pubmed/10097104
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