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Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

Human fibroblasts whose lifespan in culture has been extended by expression of a viral oncogene eventually undergo a growth crisis marked by failure to proliferate. It has been proposed that telomere shortening in these cells is the property that limits their proliferation. Here we report that ectop...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhu, Jiyue, Wang, He, Bishop, J. Michael, Blackburn, Elizabeth H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 1999
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC22361/
https://ncbi.nlm.nih.gov/pubmed/10097104
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