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Polyglutamine Genes Interact to Modulate the Severity and Progression of Neurodegeneration in Drosophila

The expansion of polyglutamine tracts in a variety of proteins causes devastating, dominantly inherited neurodegenerative diseases, including six forms of spinal cerebellar ataxia (SCA). Although a polyglutamine expansion encoded in a single allele of each of the responsible genes is sufficient for...

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Detalhes bibliográficos
Main Authors: Lessing, Derek, Bonini, Nancy M
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2235903/
https://ncbi.nlm.nih.gov/pubmed/18271626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060029
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