Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat

Large alterations in transcription accompany neurodegeneration in polyglutamine (polyQ) diseases. These pathologies manifest both general polyQ toxicity and mutant protein-specific effects. In this study, we report that the fat tumour suppressor gene mediates neurodegeneration induced by the polyQ p...

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Detaylı Bibliyografya
Asıl Yazarlar: Napoletano, Francesco, Occhi, Simona, Calamita, Piera, Volpi, Vera, Blanc, Eric, Charroux, Bernard, Royet, Julien, Fanto, Manolis
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049215/
https://ncbi.nlm.nih.gov/pubmed/21278706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.1
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