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GADD45 induction of a G(2)/M cell cycle checkpoint

G(1)/S and G(2)/M cell cycle checkpoints maintain genomic stability in eukaryotes in response to genotoxic stress. We report here both genetic and functional evidence of a Gadd45-mediated G(2)/M checkpoint in human and murine cells. Increased expression of Gadd45 via microinjection of an expression...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Wang, Xin Wei, Zhan, Qimin, Coursen, Jill D., Khan, Mohammed A., Kontny, H. Udo, Yu, Lijia, Hollander, M. Christine, O’Connor, Patrick M., Fornace, Albert J., Harris, Curtis C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22358/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097101/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3706
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