THE HYDROLYSIS OF URIDINE CYCLIC PHOSPHONATE CATALYZED BY RIBONUCLEASE-A: IMPLICATIONS FOR THE MECHANISM OF ACTION OF THE ENZYME

Uridine 2′,3′-cyclic phosphonate (I) is slowly hydrolyzed by ribonuclease-A with k(2) and K(m) values at pH6 that are respectively 1900 and 15 times smaller than the same parameters at the same pH for the related phosphate (II). Since the ratio of rate constants for hydroxide ion catalyzed hydrolysi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Harris, M. R., Usher, D. A., Albrecht, H. P., Jones, G. H., Moffatt, J. G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1969
Assuntos:	Physical Sciences: Chemistry
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC223554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5257121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.63.2.246
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