THE HYDROLYSIS OF URIDINE CYCLIC PHOSPHONATE CATALYZED BY RIBONUCLEASE-A: IMPLICATIONS FOR THE MECHANISM OF ACTION OF THE ENZYME

Uridine 2′,3′-cyclic phosphonate (I) is slowly hydrolyzed by ribonuclease-A with k(2) and K(m) values at pH6 that are respectively 1900 and 15 times smaller than the same parameters at the same pH for the related phosphate (II). Since the ratio of rate constants for hydroxide ion catalyzed hydrolysi...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Harris, M. R., Usher, D. A., Albrecht, H. P., Jones, G. H., Moffatt, J. G.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1969
Предметы:	Physical Sciences: Chemistry
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC223554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5257121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.63.2.246
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