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THE ENZYMATIC TERMINATION OF POLYDEOXYNUCLEOTIDES BY 2′,3′-DIDEOXYADENOSINE TRIPHOSPHATE

The nucleoside 2′,3′-dideoxyadenosine is lethal to E. coli and blocks DNA synthesis irreversibly. The hypothesis that a derived dideoxynucleoside triphosphate is incorporated terminally into the cellular DNA has been tested in an in vitro system. The triphosphate of dideoxyadenosine was synthesized...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Toji, Lorraine, Cohen, Seymour S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1969
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC223533/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4899881/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.63.3.871
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