Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma

Mutations of the TP53 tumor suppressor gene have been associated with poor survival in some series of diffuse large B-cell lymphoma (DLBCL) but not in other studies. The purpose of this study was to identify the frequency of TP53 alterations (mutations or deletions), characterize the gene expression...

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Main Authors: Young, Ken H., Weisenburger, Dennis D., Dave, Bhavana J., Smith, Lynette, Sanger, Warren, Iqbal, Javeed, Campo, Elias, Delabie, Jan, Gascoyne, Randy D., Ott, German, Rimsza, Lisa, Müller-Hermelink, H. Konrad, Jaffe, Elaine S., Rosenwald, Andreas, Staudt, Louis M., Chan, Wing C., Greiner, Timothy C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234786/
https://ncbi.nlm.nih.gov/pubmed/17881637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-072082
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