Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity

We investigated whether atorvastatin (AT) was capable of protecting animals from acute graft-versus-host disease (aGVHD) across major histocompatibility complex (MHC) mismatch barriers. AT treatment of the donor induced a Th-2 cytokine profile in the adoptively transferred T cells and reduced their...

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Main Authors: Zeiser, Robert, Youssef, Sawsan, Baker, Jeanette, Kambham, Neeraja, Steinman, Lawrence, Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2007
Assuntos:
Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234784/
https://ncbi.nlm.nih.gov/pubmed/17827390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-106005
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