A Lack of Thyroid Hormones Rather than Excess Thyrotropin Causes Abnormal Skeletal Development in Hypothyroidism

By proposing TSH as a key negative regulator of bone turnover, recent studies in TSH receptor (TSHR) null mice challenged the established view that skeletal responses to disruption of the hypothalamic-pituitary-thyroid axis result from altered thyroid hormone (T(3)) action in bone. Importantly, this...

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Main Authors: Bassett, J. H. Duncan, Williams, Allan J., Murphy, Elaine, Boyde, Alan, Howell, Peter G. T., Swinhoe, Rowan, Archanco, Marta, Flamant, Frédéric, Samarut, Jacques, Costagliola, Sabine, Vassart, Gilbert, Weiss, Roy E., Refetoff, Samuel, Williams, Graham R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Endocrine Society 2008
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234586/
https://ncbi.nlm.nih.gov/pubmed/17932107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0221
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