A Lack of Thyroid Hormones Rather than Excess Thyrotropin Causes Abnormal Skeletal Development in Hypothyroidism

By proposing TSH as a key negative regulator of bone turnover, recent studies in TSH receptor (TSHR) null mice challenged the established view that skeletal responses to disruption of the hypothalamic-pituitary-thyroid axis result from altered thyroid hormone (T(3)) action in bone. Importantly, this...

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Bibliographic Details
Main Authors:	Bassett, J. H. Duncan, Williams, Allan J., Murphy, Elaine, Boyde, Alan, Howell, Peter G. T., Swinhoe, Rowan, Archanco, Marta, Flamant, Frédéric, Samarut, Jacques, Costagliola, Sabine, Vassart, Gilbert, Weiss, Roy E., Refetoff, Samuel, Williams, Graham R.
Format:	Artigo
Language:	Inglês
Published:	The Endocrine Society 2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2234586/ https://ncbi.nlm.nih.gov/pubmed/17932107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0221
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A Lack of Thyroid Hormones Rather than Excess Thyrotropin Causes Abnormal Skeletal Development in Hypothyroidism

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