All-trans-retinal Is a Closed-state Inhibitor of Rod Cyclic Nucleotide–gated Ion Channels

Rod vision begins when 11-cis-retinal absorbs a photon and isomerizes to all-trans-retinal (ATR) within the photopigment, rhodopsin. Photoactivated rhodopsin triggers an enzyme cascade that lowers the concentration of cGMP, thereby closing cyclic nucleotide–gated (CNG) ion channels. After isomerizat...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: McCabe, Sarah L., Pelosi, Diana M., Tetreault, Michelle, Miri, Andrew, Nguitragool, Wang, Kovithvathanaphong, Pranisa, Mahajan, Rahul, Zimmerman, Anita L.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2004
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234497/
https://ncbi.nlm.nih.gov/pubmed/15078915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409011
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires