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All-trans-retinal Is a Closed-state Inhibitor of Rod Cyclic Nucleotide–gated Ion Channels
Rod vision begins when 11-cis-retinal absorbs a photon and isomerizes to all-trans-retinal (ATR) within the photopigment, rhodopsin. Photoactivated rhodopsin triggers an enzyme cascade that lowers the concentration of cGMP, thereby closing cyclic nucleotide–gated (CNG) ion channels. After isomerizat...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234497/ https://ncbi.nlm.nih.gov/pubmed/15078915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409011 |
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