Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins

In all eukaryotic cells, origins of DNA replication are characterized by the binding of the origin recognition complex (ORC). How ORC is positioned to sites where replication initiates is unknown, because metazoan ORC binds DNA without apparent sequence specificity. Thus, additional factors might be...

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Autors principals: Thomae, Andreas W., Pich, Dagmar, Brocher, Jan, Spindler, Mark-Peter, Berens, Christian, Hock, Robert, Hammerschmidt, Wolfgang, Schepers, Aloys
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234206/
https://ncbi.nlm.nih.gov/pubmed/18234858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707260105
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