IL-2– and IL-15–induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4(+) T lymphocytes

We examined functional status, activation mechanisms, and biologic role of the mTORC1 signaling pathway in malignant CD4(+) T cells derived from the cutaneous T-cell lymphoma (CTCL). Whereas the spontaneously growing CTCL-derived cell lines displayed persistent activation of the TORC1 as well as the...

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Autores principales: Marzec, Michal, Liu, Xiaobin, Kasprzycka, Monika, Witkiewicz, Agnieszka, Raghunath, Puthiyaveettil N., El-Salem, Mouna, Robertson, Erle, Odum, Niels, Wasik, Mariusz A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2008
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234054/
https://ncbi.nlm.nih.gov/pubmed/18025151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-095182
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