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An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation
Pathogenic activation of the LMO2 proto-oncogene by an oncoretroviral vector insertion in a clinical trial for X-linked severe combined immunodeficiency (X-SCID) has prompted safety concerns. We used an adeno-associated virus vector to achieve targeted insertion of a γ-retroviral long terminal repea...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234041/ https://ncbi.nlm.nih.gov/pubmed/17991809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-085506 |
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