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Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here, we show that during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest. Reconstitution of primary FAK-/-p21-/-fibroblasts revealed that FAK, in a...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234035/ https://ncbi.nlm.nih.gov/pubmed/18206965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.11.031 |
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