Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation

FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here, we show that during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest. Reconstitution of primary FAK-/-p21-/-fibroblasts revealed that FAK, in a...

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Detalhes bibliográficos
Main Authors: Lim, Ssang-Taek, Chen, Xiao Lei, Lim, Yangmi, Hanson, Dan A., Vo, Thanh-Trang, Howerton, Kyle, Larocque, Nicholas, Fisher, Susan J., Schlaepfer, David D., Ilic, Dusko
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234035/
https://ncbi.nlm.nih.gov/pubmed/18206965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.11.031
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