Interdomain Interactions within Ryanodine Receptors Regulate Ca(2)+ Spark Frequency in Skeletal Muscle

DP4 is a 36-residue synthetic peptide that corresponds to the Leu(2442)-Pro(2477) region of RyR1 that contains the reported malignant hyperthermia (MH) mutation site. It has been proposed that DP4 disrupts the normal interdomain interactions that stabilize the closed state of the Ca(2)+ release chan...

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Main Authors: Shtifman, Alexander, Ward, Christopher W., Yamamoto, Takeshi, Wang, Jianli, Olbinski, Beth, Valdivia, Hector H., Ikemoto, Noriaki, Schneider, Martin F.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2002
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233852/
https://ncbi.nlm.nih.gov/pubmed/11773235
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