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In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide–Gated Channels as Camp Sensors

Phosphodiesterases (PDEs) catalyze the hydrolysis of the second messengers cAMP and cGMP. However, little is known about how PDE activity regulates cyclic nucleotide signals in vivo because, outside of specialized cells, there are few methods with the appropriate spatial and temporal resolution to m...

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Sonraí Bibleagrafaíochta
Main Authors: Rich, Thomas C., Tse, Tonia E., Rohan, Joyce G., Schaack, Jerome, Karpen, Jeffrey W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2001
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233745/
https://ncbi.nlm.nih.gov/pubmed/11429444
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