In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide–Gated Channels as Camp Sensors

Phosphodiesterases (PDEs) catalyze the hydrolysis of the second messengers cAMP and cGMP. However, little is known about how PDE activity regulates cyclic nucleotide signals in vivo because, outside of specialized cells, there are few methods with the appropriate spatial and temporal resolution to m...

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Autores principales: Rich, Thomas C., Tse, Tonia E., Rohan, Joyce G., Schaack, Jerome, Karpen, Jeffrey W.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2001
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233745/
https://ncbi.nlm.nih.gov/pubmed/11429444
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