Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response

1. We constructed rat homologues (S252F and +L264) of two human α4 nicotinic mutations - α4(S248F) and α4(777ins3) - that have been linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) and co-expressed them with wild-type rat β2 subunits in Xenopus oocytes. 2. The S252F and +L264 mu...

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Detalhes bibliográficos
Main Authors: Figl, Antonio, Viseshakul, Nareerat, Shafaee, Navid, Forsayeth, John, Cohen, Bruce N
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1998
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2231326/
https://ncbi.nlm.nih.gov/pubmed/9824708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1998.655ba.x
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