Antisense to MDR1 mRNA reduces P-glycoprotein expression, swelling-activated Cl(−) current and volume regulation in bovine ciliary epithelial cells

1. Native ciliary epithelial cells from the ciliary epithelium of the eye exhibit anti-P-glycoprotein (P-gp) immunofluorescence. 2. We have used an antisense ‘knock-down’ approach to investigate the relationship between P-gp and the volume-activated chloride current (I(Cl,swell)) and its role in vol...

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Hlavní autoři: Wang, Liwei, Chen, Lixin, Walker, Veronica, Jacob, Tim J C
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 1998
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2231096/
https://ncbi.nlm.nih.gov/pubmed/9679161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1998.033bi.x
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