Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats

Thyroid hormone is a critical determinant of cellular metabolism and differentiation. Precise tissue-specific regulation of the active ligand 3,5,3′-triiodothyronine (T3) is achieved by the sequential removal of iodine groups from the thyroid hormone molecule, with type 3 deiodinase (D3) comprising...

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Detalhes bibliográficos
Main Authors: Simonides, Warner S., Mulcahey, Michelle A., Redout, Everaldo M., Muller, Alice, Zuidwijk, Marian J., Visser, Theo J., Wassen, Frank W.J.S., Crescenzi, Alessandra, da-Silva, Wagner S., Harney, John, Engel, Felix B., Obregon, Maria-Jesús, Larsen, P. Reed, Bianco, Antonio C., Huang, Stephen A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230657/
https://ncbi.nlm.nih.gov/pubmed/18259611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32824
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