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Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem?

Recent studies in various rodent models of pathologic ventricular hypertrophy report the re-expression of deiodinase type 3 (D3) in cardiomyocytes. D3 inactivates thyroid hormone (T3) and is mainly expressed in tissues during development. The stimulation of D3 activity in ventricular hypertrophy and...

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Hlavní autoři: Pol, Christine J., Muller, Alice, Simonides, Warner S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820687/
https://ncbi.nlm.nih.gov/pubmed/19107595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10741-008-9133-7
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