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Recombinant human activated protein C: current insights into its mechanism of action

Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and prevent propagation of thrombin generation and formation of microvascular thrombosis. Furth...

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Detalhes bibliográficos
Main Authors: Levi, Marcel, van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230607/
https://ncbi.nlm.nih.gov/pubmed/18269690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc6154
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