Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production.

BACKGROUND: The hydrophilic bile salt ursodeoxycholate (UDCA) inhibits injury by hydrophobic bile acids and is used to treat cholestatic liver diseases. Interestingly, hepatocyte cell death from bile acid-induced toxicity occurs more frequently from apoptosis than from necrosis. However, both proces...

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Detalhes bibliográficos
Main Authors: Rodrigues, C. M., Fan, G., Wong, P. Y., Kren, B. T., Steer, C. J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Feinstein Institute for Medical Research 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230355/
https://ncbi.nlm.nih.gov/pubmed/9562975
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