Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors.

BACKGROUND: Vectors based on herpes simplex virus type 1 (HSV-1) can efficiently transduce hepatocytes in the mouse liver, and vector genomes can persist for at least 2 months. However, 24 hr after gene transfer, the number of cells that express the transgene decreases rapidly and no transduced cell...

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Detalhes bibliográficos
Main Authors: Fraefel, C., Jacoby, D. R., Lage, C., Hilderbrand, H., Chou, J. Y., Alt, F. W., Breakefield, X. O., Majzoub, J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Feinstein Institute for Medical Research 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230287/
https://ncbi.nlm.nih.gov/pubmed/9440115
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