Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait.

BACKGROUND: Human falciparum malaria, caused by the intracellular protozoa Plasmodium falciparum, results in 1-2 million deaths per year. P. falciparum digests host erythrocyte hemoglobin within its food vacuole, resulting in the release of potentially toxic free heme. A parasite-specific heme polym...

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Autori principali: Martiney, J. A., Cerami, A., Slater, A. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Feinstein Institute for Medical Research 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230121/
https://ncbi.nlm.nih.gov/pubmed/8726466
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