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VH3-21 B cells escape from a state of tolerance in rheumatoid arthritis and secrete rheumatoid factor.

BACKGROUND: Rheumatoid factor (RF) is a characteristic but not pathognomic feature in patients with rheumatoid arthritis (RA). It is unknown whether the repertoire of immunoglobulin genes utilized by RF+ B cells of RA patients is unique and whether RF+ B cells in normal individuals are silenced or d...

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Detalhes bibliográficos
Main Authors: He, X., Goronzy, J. J., Zhong, W., Xie, C., Weyand, C. M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Feinstein Institute for Medical Research 1995
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230015/
https://ncbi.nlm.nih.gov/pubmed/8612199
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