Cell type-dependent modulation of the dominant negative action of human mutant thyroid hormone beta 1 receptors.

BACKGROUND: Mutations in the ligand-binding domain of the thyroid hormone receptor beta (TR beta) gene cause the syndrome of resistance to thyroid hormone (RTH). The clinical phenotype results from the antagonism of the normal TR alpha and the non-mutated TR beta alleles by the TR beta 1 mutants, vi...

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Autors principals: Wong, R., Zhu, X. G., Pineda, M. A., Cheng, S. Y., Weintraub, B. D.
Format: Artigo
Idioma:Inglês
Publicat: The Feinstein Institute for Medical Research 1995
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229906/
https://ncbi.nlm.nih.gov/pubmed/8529109
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