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rIFN-γ-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition

BACKGROUND: Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-γ (rIFN-γ), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC). METHODS: We examined EOC cell lines for the expression of arginase in a...

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Udgivet i:J Transl Med
Principais autores: Melichar, Bohuslav, Hu, Wei, Patenia, Rebecca, Melicharová, Karolina, Gallardo, Stacie T, Freedman, Ralph
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2003
Fag:
Research
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC222988/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14572312/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1479-5876-1-5
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