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External Barium Affects the Gating of KCNQ1 Potassium Channels and Produces a Pore Block via Two Discrete Sites

The pore properties and the reciprocal interactions between permeant ions and the gating of KCNQ channels are poorly understood. Here we used external barium to investigate the permeation characteristics of homomeric KCNQ1 channels. We assessed the Ba(2+) binding kinetics and the concentration and v...

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Main Authors: Gibor, Gilad, Yakubovich, Daniel, Peretz, Asher, Attali, Bernard
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229603/
https://ncbi.nlm.nih.gov/pubmed/15226366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409068
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