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Side-chain Charge Effects and Conductance Determinants in the Pore of ClC-0 Chloride Channels
The charge on the side chain of the internal pore residue lysine 519 (K519) of the Torpedo ClC-0 chloride (Cl(−)) channel affects channel conductance. Experiments that replace wild-type (WT) lysine with neutral or negatively charged residues or that modify the K519C mutant with various methane thios...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2229543/ https://ncbi.nlm.nih.gov/pubmed/12885875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308844 |
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