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External TEA Block of Shaker K(+) Channels Is Coupled to the Movement of K(+) Ions within the Selectivity Filter

Recent molecular dynamic simulations and electrostatic calculations suggested that the external TEA binding site in K(+) channels is outside the membrane electric field. However, it has been known for some time that external TEA block of Shaker K(+) channels is voltage dependent. To reconcile these...

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Autori principali: Thompson, Jill, Begenisich, Ted
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229542/
https://ncbi.nlm.nih.gov/pubmed/12885878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308848
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