Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter-induced transformation in mouse epidermal JB6 cells and for progression in mouse and human keratinocytes. Until now, the q...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Young, Matthew R., Li, Jian-Jian, Rincón, Mercedes, Flavell, Richard A., Sathyanarayana, B. K., Hunziker, Rosemarie, Colburn, Nancy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22295/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449779/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.17.9827
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