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A unique role for the S4 segment of domain 4 in the inactivation of sodium channels
Sodium channels have four homologous domains (D1-D4) each with six putative transmembrane segments (S1-S6). The highly charged S4 segments in each domain are postulated voltage sensors for gating. We made 15 charge-neutralizing or -reversing substitutions in the first or third basic residues (argini...
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| Format: | Artigo |
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| Language: | Inglês |
| Published: |
The Rockefeller University Press
1996
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2229343/ https://ncbi.nlm.nih.gov/pubmed/8972392 |
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