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Specificity for block by saxitoxin and divalent cations at a residue which determines sensitivity of sodium channel subtypes to guanidinium toxins

bTyrosine 401 of the skeletal muscle isoform (mu 1) of the rat muscle Na channel is an important determinant of high affinity block by tetrodotoxin (TTX) and saxitoxin (STX) in Na-channel isoforms. In mammalian heart Na channels, this residue is substituted by cysteine, which results in low affinity...

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Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1995
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229260/
https://ncbi.nlm.nih.gov/pubmed/8537816
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