Block of sodium channels by divalent mercury: role of specific cysteinyl residues in the P-loop region.

Divalent mercury (Hg(2+)) blocked human skeletal Na(+) channels (hSkM1) in a stable dose-dependent manner (K(d) = 0.96 microM) in the absence of reducing agent. Dithiothreitol (DTT) significantly prevented Hg(2+) block of hSkM1, and Hg(2+) block was also readily reversed by DTT. Both thimerosal and...

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Detalhes bibliográficos
Main Authors: Hisatome, I, Kurata, Y, Sasaki, N, Morisaki, T, Morisaki, H, Tanaka, Y, Urashima, T, Yatsuhashi, T, Tsuboi, M, Kitamura, F, Miake, J, Takeda, S i, Taniguchi, S i, Ogino, K, Igawa, O, Yoshida, A, Sato, R, Makita, N, Shigemasa, C
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301028/
https://ncbi.nlm.nih.gov/pubmed/10968996
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