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Binding affinity and stereoselectivity of local anesthetics in single batrachotoxin-activated Na+ channels

Several local anesthetics (LA) have been previously shown to block muscle batrachotoxin (BTX)-activated Na+ channels in planar bilayers. The mean dwell time of different LA drugs, however, varies widely, from less than 10 ms to longer than several seconds. In this study, we have examined the structu...

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Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1990
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229022/
https://ncbi.nlm.nih.gov/pubmed/2177771
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