Accelerated Telomere Shortening and Replicative Senescence in Human Fibroblasts Overexpressing Mutant and Wild Type Lamin A

LMNA mutations are responsible for a variety of genetic disorders, including muscular dystrophy, lipodystrophy, and certain progeroid syndromes, notably Hutchinson-Gilford Progeria. Although a number of clinical features of these disorders are suggestive of accelerated aging, it is not known whether...

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Main Authors: Huang, Shurong, Risques, Rosa Ana, Martin, George M., Rabinovitch, Peter S., Oshima, Junko
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228272/
https://ncbi.nlm.nih.gov/pubmed/17870066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2007.08.004
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