Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.

The chemistry of the mitomycin C-related drug indoloquinone EO9 would suggest that its mechanism of action is likely to involve DNA damage after reductive activation. The ability of this agent to induce DNA damage in intact cells has been examined using alkaline filter elution. After treatment with...

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Bibliographic Details
Main Authors: Bailey, S. M., Wyatt, M. D., Friedlos, F., Hartley, J. A., Knox, R. J., Lewis, A. D., Workman, P.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228210/
https://ncbi.nlm.nih.gov/pubmed/9413948
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