Up-regulation of p21WAF1 expression in myeloid cells is activated by the protein kinase C pathway.

Phorbol-12-myristate-13-acetate (PMA) induces p21WAF-1 expression in human myeloid leukaemic HL-60 cells. We show that this induction is specifically mediated by protein kinase C (PKC). In addition, the PKC inhibitor Ro 31-8220 with predominant PKC-alpha isoform specificity almost completely inhibit...

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Detalhes bibliográficos
Main Authors: Schwaller, J., Peters, U. R., Pabst, T., Niklaus, G., Macfarlane, D. E., Fey, M. F., Tobler, A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228197/
https://ncbi.nlm.nih.gov/pubmed/9413940
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