Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069.

P450 reductase (NADPH: cytochrome c (P450) reductase, EC 1.6.2.4) plays an important role in the reductive activation of the bioreductive drug tirapazamine (SR4233). Thus, in a panel of human breast cancer cell lines, expression of P450 reductase correlated with both the hypoxic toxicity and the met...

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Autori principali: Patterson, A. V., Saunders, M. P., Chinje, E. C., Talbot, D. C., Harris, A. L., Strafford, I. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1997
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228151/
https://ncbi.nlm.nih.gov/pubmed/9374381
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