Murine P-glycoprotein on stromal vessels mediates multidrug resistance in intracerebral human glioma xenografts.

Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, plays a role. We studied drug sensitivity to vincristine (VCR), doxorubicin (DOX) and nimustine...

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Main Authors: Takamiya, Y., Abe, Y., Tanaka, Y., Tsugu, A., Kazuno, M., Oshika, Y., Maruo, K., Ohnishi, Y., Sato, O., Yamazaki, H., Kijima, H., Ueyama, Y., Tamaoki, N., Nakamura, M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2227999/
https://ncbi.nlm.nih.gov/pubmed/9275020
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