Amplified Expression Profiling of Platelet Transcriptome Reveals Changes in Arginine Metabolic Pathways in Patients With Sickle Cell Disease

BACKGROUND: In sickle cell disease, ischemia-reperfusion injury and intravascular hemolysis produce endothelial dysfunction and vasculopathy characterized by reduced nitric oxide and arginine bioavailability. Recent functional studies of platelets in patients with sickle cell disease reveal a basall...

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Detalhes bibliográficos
Main Authors: Raghavachari, Nalini, Xu, Xiuli, Harris, Amy, Villagra, Jose, Logun, Carolea, Barb, Jennifer, Solomon, Michael A., Suffredini, Anthony F., Danner, Robert L., Kato, Gregory, Munson, Peter J., Morris, Sidney M., Gladwin, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225987/
https://ncbi.nlm.nih.gov/pubmed/17353439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.106.658641
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