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Dimerization of zinc fingers mediated by peptides evolved in vitro from random sequences

Peptides that mediate dimerization of attached zinc finger DNA-binding domains have been evolved in vitro starting from random sequences. We first used phage display to select dimerization elements from libraries of random 15-residue polypeptides that were fused to the N terminus of the zinc finger...

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Bibliografske podrobnosti
Main Authors: Wang, Bryan S., Pabo, Carl O.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC22249/
https://ncbi.nlm.nih.gov/pubmed/10449733
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