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A Sphingolipid Inhibitor Induces a Cytokinesis Arrest and Blocks Stage Differentiation in Giardia lamblia

Sphingolipid biosynthesis pathways have recently emerged as a promising target for therapeutic intervention against pathogens, including parasites. A key step in the synthesis of complex sphingolipids is the glucosylation of ceramide, mediated by glucosylceramide (GlcCer) synthase, whose activity ca...

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Bibliographic Details
Main Authors: Sonda, Sabrina, Štefanić, Saša, Hehl, Adrian B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224734/
https://ncbi.nlm.nih.gov/pubmed/18086854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01105-07
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