A Conserved Motif in Region V of the Large Polymerase Proteins of Nonsegmented Negative-Sense RNA Viruses That Is Essential for mRNA Capping

Nonsegmented negative-sense (NNS) RNA viruses cap their mRNA by an unconventional mechanism. Specifically, 5′ monophosphate mRNA is transferred to GDP derived from GTP through a reaction that involves a covalent intermediate between the large polymerase protein L and mRNA. This polyribonucleotidyltr...

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Detalhes bibliográficos
Main Authors: Li, Jianrong, Rahmeh, Amal, Morelli, Marco, Whelan, Sean P. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224588/
https://ncbi.nlm.nih.gov/pubmed/18003731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02107-07
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