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Complete In Vitro Reconstitution of Adeno-Associated Virus DNA Replication Requires the Minichromosome Maintenance Complex Proteins

Adeno-associated virus (AAV) replicates its DNA exclusively by a leading-strand DNA replication mechanism and requires coinfection with a helper virus, such as adenovirus, to achieve a productive infection. In previous work, we described an in vitro AAV replication assay that required the AAV termin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nash, Kevin, Chen, Weijun, Muzyczka, Nicholas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224442/
https://ncbi.nlm.nih.gov/pubmed/18057257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01968-07
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