A Naturally Occurring Deletion in Its NS Gene Contributes to the Attenuation of an H5N1 Swine Influenza Virus in Chickens

In 2001 and 2003, we isolated two H5N1 viruses, A/swine/Fujian/1/01 (SW/FJ/01) and A/swine/Fujian/1/03 (SW/FJ/03), from pigs in Fujian Province, southern China. Genetically, these two viruses are similar, although the NS gene of the SW/FJ/03 virus has a 15-nucleotide deletion at coding positions 612...

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Autores principales: Zhu, Qiyun, Yang, Huanliang, Chen, Weiye, Cao, Wenyan, Zhong, Gongxun, Jiao, Peirong, Deng, Guohua, Yu, Kangzhen, Yang, Chinglai, Bu, Zhigao, Kawaoka, Yoshihiro, Chen, Hualan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224367/
https://ncbi.nlm.nih.gov/pubmed/17942562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00978-07
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